Director, Biology- SK Life Science Labs

As a Director of Biology, you will co-lead multi-disciplinary teams to identify, develop, and implement methods to support Target ID, Biomarkers, Patient Stratification, and Mechanism of Action for the development of protein degraders for oncology, immune-oncology, immunology and other therapeutic areas. You will work in collaboration with chemistry, structural biology, DMPK, bioinformatics, and additional matrixed team members to drive programs through all phases of drug discovery and translational science.

• Serve as a senior member of biology department
• Lead a multi-functional drug discovery project team with a chemistry co-leader to drive every aspect of the project, including scientific decisions and budgetary proposals
• Responsible (with chemistry co-project leader) for delivery of development compounds
• Lead a team of biologists who are responsible for the design, development, and execution of in vitro and in vivo assays to support progression of the programs
• Move programs forward in a fast-paced environment
• Interpret, summarize, and present research findings at internal and external scientific meetings
• Provide advice of budget and staff projections to head of biology
• Responsible for end-to-end discovery biology including target identification, validation, pharmacology, biomarker discovery, and translational biology
• Ensure data quality and data integrity
• Lead target assessment from external sources: academia and external collaborators

• Ph.D. in Cell Biology or Molecular Biology with relevant post-doctoral experience
• 10+ years of drug discovery experience in biotech and/or pharmaceutical companies with demonstrated success in small molecule drug discovery
• Demonstrated experience in leading a small molecule oncology project from concept to development stage is highly desired
• Experience in new target discovery and biological target validation is desired
• Strong problem-solving ability in a science-driven organization is highly desired
• Strong strategic scientific and technical leadership in the design, execution, analysis, and interpretation of data to drive programs and elucidate mechanism of action
• Ability to critically analyze and interpret data, effectively document and communicate results with recommendations for next steps
• Collaborative, team-oriented mindset with strong verbal and written communication skills
• Experience in supervising bench biologists (in vitro) and CRO biologists (in vitro and in vivo) is desired
• Knowledge in small molecule protein degradation via proteosome system and deep understanding in biology of UPS is a plus
• Assay development expertise, especially in protein-degradation related cell-based assays is desired